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From Boston:
Take Route 24 south to I-495 south or take Route 3 south to the Sagamore Bridge.

From Springfield / Worcester:
Take Mass Turnpike to I-495 south.  Before Bourne Bridge take route 6 east along the Cape Cod Canal to the Sagamore Bridge.

From New York / Connecticut:
Take I-95 to Providence, RI, and then take I-195 east to Route 25 east and follow the Sagamore Bridge.

From Sagamore Bridge: 
Cross the Sagamore Bridge and follow Route 6 to exit 9A.  Merge right onto Route 134.  Take a left on Route 28 (Main Street) and then take a right onto Depot Street.  Follow Depot Street to Old Wharf Road and turn right onto Old Wharf Road.  The Cutty Sark is ¼ mile on your right.